Analysis of OXA-204 carbapenemase-producing Enterobacteriaceae reveals possible endoscopy-associated transmission, France, 2012 to 2014
File(s)
Author(s)
Type
Journal Article
Abstract
OXA-48-like beta-lactamase producing bacteria are
now endemic in several European and Mediterranean
countries. Among this carbapenemase family, the OXA-
48 and OXA-181 variants predominate, whereas other
variants such as OXA-204 are rarely reported. Here,
we report the molecular epidemiology of a collection
of OXA-204-positive enterobacterial isolates (n
= 29)
recovered in France between October 2012 and May
2014. This study describes the first outbreak of OXA-
204-producing
Enterobacteriaceae
in Europe, involving
12 isolates of an ST90
Escherichia coli
clone and nine
isolates of an ST147
Klebsiella pneumoniae
clone. All
isolates co-produced the
cephalosporinase CMY-4,
and 60% of them co-produced the extended-spectrum
beta-lactamase CTX-M-15. The
bla
OX A-204
gene was
located on a 150-kb
IncA/C plasmid, isolated from
various enterobacterial species in the same patient,
indicating a high conjugative ability of this genetic
vehicle.
now endemic in several European and Mediterranean
countries. Among this carbapenemase family, the OXA-
48 and OXA-181 variants predominate, whereas other
variants such as OXA-204 are rarely reported. Here,
we report the molecular epidemiology of a collection
of OXA-204-positive enterobacterial isolates (n
= 29)
recovered in France between October 2012 and May
2014. This study describes the first outbreak of OXA-
204-producing
Enterobacteriaceae
in Europe, involving
12 isolates of an ST90
Escherichia coli
clone and nine
isolates of an ST147
Klebsiella pneumoniae
clone. All
isolates co-produced the
cephalosporinase CMY-4,
and 60% of them co-produced the extended-spectrum
beta-lactamase CTX-M-15. The
bla
OX A-204
gene was
located on a 150-kb
IncA/C plasmid, isolated from
various enterobacterial species in the same patient,
indicating a high conjugative ability of this genetic
vehicle.
Date Issued
2017-12-07
Date Acceptance
2017-05-23
Citation
Eurosurveillance, 2017, 22 (49), pp.15-22
ISSN
1560-7917
Publisher
European Centre for Disease Prevention and Control
Start Page
15
End Page
22
Journal / Book Title
Eurosurveillance
Volume
22
Issue
49
Copyright Statement
© 2017 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000417378100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
D BETA-LACTAMASE
KLEBSIELLA-PNEUMONIAE
ESCHERICHIA-COLI
BIOCHEMICAL-CHARACTERIZATION
EMERGENCE
PLASMIDS
TUNISIA
EXPRESSION
RESISTANCE
FEATURES
Publication Status
Published
Article Number
ARTN 17-00048