New advances in menopause symptom management
File(s)
Author(s)
Koysombat, Kanyada
McGown, Patrick
Nyunt, Sandhi
Abbara, Ali
Dhillo, Waljit S
Type
Journal Article
Abstract
Vasomotor symptoms (VMS) are characteristic of menopause experienced by over 75% of postmenopausal women with significant health and socioeconomic implications. Although the average duration of symptoms is seven years, 10% of women experience symptoms for more than a decade. Although menopausal hormone therapy (MHT) remains an efficacious and cost-effective treatment, its use may not be suitable in all women, such as those at an increased risk of breast cancer or gynaecological malignancy. The neurokinin B (NKB) signaling pathway, together with its intricate connection to the median preoptic nucleus (MnPO), has been postulated to provide integrated reproductive and thermoregulatory responses, with a central role in mediating postmenopausal VMS. This review describes the physiological hypothalamo-pituitary-ovary (HPO) axis, and subsequently the neuroendocrine changes that occur with menopause using evidence derived from animal and human studies. Finally, data from the latest clinical trials using novel therapeutic agents that antagonise NKB signaling are reviewed.
Date Issued
2024-01-01
Date Acceptance
2023-04-01
Citation
Best Practice and Research: Clinical Endocrinology and Metabolism, 2024, 38 (1), pp.1-17
ISSN
1521-690X
Publisher
Elsevier
Start Page
1
End Page
17
Journal / Book Title
Best Practice and Research: Clinical Endocrinology and Metabolism
Volume
38
Issue
1
Copyright Statement
Copyright © 2023 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/37076317
PII: S1521-690X(23)00045-3
Subjects
hot flushes
Menopause
neurokinin 3 receptor antagonist
neurokinin B
vasomotor symptoms
Publication Status
Published
Coverage Spatial
Netherlands
Article Number
ARTN 101774
Date Publish Online
2023-04-11