Control of invasive salmonella disease in Africa: Is there a role for human challenge models?
Author(s)
Gibani, Malick M
Jin, Celina
Darton, Thomas C
Pollard, Andrew J
Type
Journal Article
Abstract
Invasive Salmonella disease in Africa is a major public health concern. With evidence of the transcontinental spread of the Salmonella Typhi H58 haplotype, improved estimates of the burden of infection and understanding of the complex interplay of factors affecting disease transmission are needed to assist with efforts aimed at disease control. In addition to Salmonella Typhi, invasive nontyphoidal Salmonella are increasingly recognized as an important cause of febrile illness and mortality in sub-Saharan Africa. Human experimental oral challenge studies with Salmonella can be used as a model to offer unique insights into host–pathogen interactions as well as a platform to efficiently test new diagnostic and vaccine candidates. In this article, we review the background and use of human challenge studies to date and discuss how findings from these studies may lead to progress in the control of invasive Salmonella disease in Africa.
Date Issued
2015-11-01
Date Acceptance
2015-10-01
Citation
Clinical Infectious Diseases, 2015, 61 (suppl_4), pp.S266-S271
ISSN
1058-4838
Publisher
Oxford University Press (OUP)
Start Page
S266
End Page
S271
Journal / Book Title
Clinical Infectious Diseases
Volume
61
Issue
suppl_4
Copyright Statement
© 2015 The Author. Published by Oxford University Press on behalf of the Infectious
Diseases Societyof America. This is an Open Accessarticle distributed undertheterms
of the Creative Commons Attribution License (http://creativecommons.org/licenses/
by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any
medium, provided the original work is properly cited.
Diseases Societyof America. This is an Open Accessarticle distributed undertheterms
of the Creative Commons Attribution License (http://creativecommons.org/licenses/
by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any
medium, provided the original work is properly cited.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000362955100005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Microbiology
human challenge study
controlled human infection study
typhoid fever
Salmonella Typhi
invasive nontyphoidal Salmonella
ENTERICA SEROVAR TYPHI
IMMUNOLOGIC CONTROL
INFECTIONS
FEVER
TRANSMISSION
VACCINE
CHILDREN
SEROTYPE
PATHOGENESIS
VOLUNTEERS
Publication Status
Published
Date Publish Online
2015-10-07