Fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy
File(s)
Author(s)
Huang, Yu
Qiu, Feng
Chen, Rongjun
Yan, Deyue
Zhu, Xinyuan
Type
Journal Article
Abstract
Photodynamic therapy (PDT) has received an increasing attention in disease treatment due to its minimally-invasive, selective destruction with combination of a photosensitizer (PS), light, and oxygen. However, the limited cytotoxic singlet oxygen (1O2) generation and thin tissue penetrability have been two major barriers in the conventional PDT, hindering its further development and clinical use. Recently, fluorescence resonance energy transfer-based drug delivery systems (FRET-DDSs), indirectly activating PS drugs by a donor fluorophore, have been successfully applied to alleviate these issues. The transfer of excitation energy from donors to PS drugs can significantly boost its light harvesting and extend the field of light source, which dramatically improves its production efficiency of singlet oxygen, thus leading to highly efficient and deep-tissue-penetrable PDT for the treatment of bacteria, cancer and other diseases. In this Review, we give the first-known overview of recent advances in FRET-DDSs for the enhanced PDT. In particular, dependent on the excitation energy mechanism in the FRET process, six major types of FRET-DDSs, including one-photon, two-photon, upconversion, auto-fluorescence, X-ray, and Cerenkov excited FRET-DDSs in PDT applications are summarized in detail. Furthermore, future research directions and perspectives in this emerging field are also discussed.
Date Issued
2020-05-07
Date Acceptance
2020-02-28
Citation
Journal of Materials Chemistry B, 2020, 8 (17), pp.3772-3788
ISSN
2050-750X
Publisher
Royal Society of Chemistry (RSC)
Start Page
3772
End Page
3788
Journal / Book Title
Journal of Materials Chemistry B
Volume
8
Issue
17
Copyright Statement
© The Royal Society of Chemistry 2020
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Identifier
https://pubs.rsc.org/en/Content/ArticleLanding/2020/TB/D0TB00262C#!divAbstract
Grant Number
EP/R013764/1
Subjects
0303 Macromolecular and Materials Chemistry
0903 Biomedical Engineering
Publication Status
Published
Date Publish Online
2020-02-29