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Using Laponite to deliver BMP‐2 for bone tissue engineering – in vitro, chorioallantoic membrane assay and murine subcutaneous model validation
File(s)
Author(s)
Marshall, Karen M
Wojciechowski, Jonathan P
Echalier, Cécile
Callens, Sebastien JP
Yang, Tao
Type
Journal Article
Abstract
Fracture non-union occurs due to various factors, leading to the development of potentially substantial bone defects. While autograft and allograft are the current gold standards for non-union fractures, challenges related to availability and immune rejection highlight the need for improved treatments. A strategy in bone tissue engineering is to harness growth factors to induce an effect on cells to change their phenotype, behavior and initiate signaling pathways which lead to increased matrix deposition and tissue formation. Bone morphogenetic protein-2 (BMP-2) is a potent osteogenic growth factor however, given its rapid clearance time in vivo, there is a specific therapeutic window for efficacy while avoiding potential deleterious side-effects. It is demonstrated that a Laponite nanoclay coating on a 3D printable and bioresorbable poly(caprolactone) trimethacrylate-based resin enables binding of BMP-2, decreases the rate of release, enabling reduced concentrations to be used while enhancing osteoinduction in both in vitro and in vivo models.
Date Issued
2024-10-15
Date Acceptance
2024-07-17
Citation
Advanced Materials Interfaces, 2024, 11 (29)
URI
URL
DOI
ISSN
2196-7350
Publisher
Wiley
Journal / Book Title
Advanced Materials Interfaces
Volume
11
Issue
29
Copyright Statement
© 2024 The Author(s). Advanced Materials Interfaces published by Wiley-VCH GmbH

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
http://dx.doi.org/10.1002/admi.202400332
Publication Status
Published
Article Number
2400332
Date Publish Online
2024-07-29