The aging of the AlphaFold database
File(s)
Accepted version
Accepted version
Author(s)
Tsitsa, Ifigenia
Conev, Anja
David, Alessia
Islam, Suhail A
Sternberg, Michael JE
Type
Journal Article
Abstract
The AlphaFold database, released in 2022, modeled UniProt sequences from April 2021 and now provides 200 million predicted protein structures. Of the 20,504 full-length predicted human structures, 631 entries conflict with the June 2025 UniProt release. Similar conflicts across species highlight how bioinformatics resources can rapidly age.
Date Issued
2025-12-01
Date Acceptance
2025-12-01
Citation
Nature Structural & Molecular Biology, 2025, 32 (12), pp.2374-2376
ISSN
1545-9993
Publisher
Nature Research
Start Page
2374
End Page
2376
Journal / Book Title
Nature Structural & Molecular Biology
Volume
32
Issue
12
Copyright Statement
Copyright © 2025 Springer-Verlag. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41594-025-01725-z
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/41372615
PII: 10.1038/s41594-025-01725-z
Subjects
Biochemistry & Molecular Biology
Biophysics
Cell Biology
Life Sciences & Biomedicine
Science & Technology
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2025-12-10