Selectively-sized graphene-based nanopores for in-situ single molecule sensing
File(s)
Published version
Accepted version
Author(s)
Crick, CR
Sze, JYY
Rosillo-lopez, M
Salzmann, CG
Edel, JB
Type
Journal Article
Abstract
The use of nanopore biosensors is set to be extremely important in developing precise single molecule detectors and providing highly sensitive advanced analysis of biological molecules. The precise tailoring of nanopore size is a significant step toward achieving this, as it would allow for a nanopore to be tuned to a corresponding analyte. The work presented here details a methodology for selectively opening nanopores in real-time. The tunable nanopores on a quartz nanopipette platform are fabricated using the electroetching of a graphene-based membrane constructed from individual graphene nanoflakes (ø ∼30 nm). The device design allows for in situ opening of the graphene membrane, from fully closed to fully opened (ø ∼25 nm), a feature that has yet to be reported in the literature. The translocation of DNA is studied as the pore size is varied, allowing for subfeatures of DNA to be detected with slower DNA translocations at smaller pore sizes, and the ability to observe trends as the pore is opened. This approach opens the door to creating a device that can be target to detect specific analytes.
Date Issued
2015-07-24
Date Acceptance
2015-07-24
Citation
Acs Applied Materials & Interfaces, 2015, 7 (32), pp.18188-18194
ISSN
1944-8252
Publisher
American Chemical Society
Start Page
18188
End Page
18194
Journal / Book Title
Acs Applied Materials & Interfaces
Volume
7
Issue
32
Copyright Statement
© 2015 American Chemical Society. ACS AuthorChoice - This is an open access article published under an ACS AuthorChoice License [http://pubs.acs.org/page/policy/authorchoice_termsofuse.html], which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Publication Status
Published