Background:
We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an
established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-
hip ratio, WHR), which may better reflect metabolic complications of obesity, with total obesity-related and site-specific (colorectal
and postmenopausal breast) cancer incidence.
Methods:
This is a meta-analysis of seven prospective cohort studies participating in the CHANCES consortium including 18 668
men and 24 751 women with a mean age of 62 and 63 years, respectively. Harmonised individual participant data from all seven
cohorts were analysed separately and alternatively for each anthropometric indicator using multivariable Cox proportional hazards
models.
Results:
After a median follow-up period of 12 years, 1656 first-incident obesity-related cancers (defined as postmenopausal
female breast, colorectum, lower oesophagus, cardia stomach, liver, gallbladder, pancreas, endometrium, ovary, and kidney) had
occurred in men and women. In the meta-analysis of all studies, associations between indicators of adiposity, per s.d. increment,
and risk for all obesity-related cancers combined yielded the following summary hazard ratios: 1.11 (95% CI 1.02–1.21) for BMI, 1.13
(95% CI 1.04–1.23) for WC, 1.09 (95% CI 0.98–1.21) for HC, and 1.15 (95% CI 1.00–1.32) for WHR. Increases in risk for colorectal
cancer were 16%, 21%, 15%, and 20%, respectively per s.d. of BMI, WC, HC, and WHR. Effect modification by hormone therapy
(HT) use was observed for postmenopausal breast cancer (
P
interaction
o
0.001), where never HT users showed an
B
20% increased
risk per s.d. of BMI, WC, and HC compared to ever users.
Conclusions:
BMI, WC, HC, and WHR show comparable positive associations with obesity-related cancers combined and with
colorectal cancer in older adults. For postmenopausal breast cancer we report evidence for effect modification by HT use.