In vivo model systems for hepatitis B virus research
File(s)
Accepted version
Author(s)
Ortega-Prieto, Ana Maria
Cherry, Catherine
Gunn, Harry
Dorner, Marcus
Type
Journal Article
Abstract
Hepatitis B virus (HBV) globally affects more than 257 million people, resulting in progressively worsening liver disease, manifesting as fibrosis, cirrhosis and hepatocellular carcinoma. The exceptionally narrow species tropism of HBV restricts its natural hosts to humans and non-human primates, including chimpanzees, gorillas, gibbons, and orangutans. The unavailability of completely immunocompetent small-animal models has contributed to the lack of curative therapeutic interventions. Even though surrogates allow the study of closely related viruses, their host genetic background, immune responses, and molecular virology differ to that of HBV. Various different models, based either on pure murine or xenotransplantation systems have been introduced over the past years, often making the choice of the optimal model for any given question challenging. Here, we offer a concise review into in vivo model systems employed to study HBV infection and steps in the HBV life cycle or pathogenesis.
Date Issued
2019-05-10
Date Acceptance
2018-12-12
Citation
ACS Infectious Diseases, 2019, 5 (5), pp.688-702
ISSN
2373-8227
Publisher
American Chemical Society (ACS)
Start Page
688
End Page
702
Journal / Book Title
ACS Infectious Diseases
Volume
5
Issue
5
Copyright Statement
© 2018 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Infectious Diseases, after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acsinfecdis.8b00223
Sponsor
Wellcome Trust
European Research Council
Commission of the European Communities
Grant Number
104771/Z/14/Z
637304
Subjects
Science & Technology
Life Sciences & Biomedicine
Chemistry, Medicinal
Infectious Diseases
Pharmacology & Pharmacy
hepatitis B virus
in vivo
animal model
CLOSED-CIRCULAR DNA
HUMANIZED MOUSE MODEL
LARGE ENVELOPE POLYPEPTIDE
T-CELL TOLERANCE
HEPATOCELLULAR-CARCINOMA
TRANSGENIC MOUSE
HUMAN LIVER
HUMAN HEPATOCYTES
EPIGENETIC REGULATION
ADENOVIRUS VECTORS
animal model
hepatitis B virus
in vivo
Publication Status
Published
Article Number
acsinfecdis.8b00223
Date Publish Online
2018-12-12