Microglial positron emission tomography (PET) imaging in epilepsy: applications, opportunities and pitfalls
File(s)SEIZURE-S-16-00628.pdf (1.08 MB)
Accepted version
Author(s)
Scott, G
Mahmud, M
Owen, DR
Johnson, MR
Type
Journal Article
Abstract
Neuroinflammation is increasingly implicated in epileptogenesis and epilepsy. Microglia are an important mediator of central nervous system inflammation, and the development of positron emission tomography (PET) radioligands which bind the Translocator Protein (TSPO), an outer mitochondrial membrane protein expressed by microglia, has enabled in vivo measurement of neuroinflammation. Here, we outline the principles and potential pitfalls of TSPO PET imaging in relation to epilepsy, and opportunities for using TSPO imaging as a biomarker for future anti-inflammatory based therapeutics in epilepsy.
Date Issued
2016-11-13
Date Acceptance
2016-10-27
Citation
Seizure-European Journal of Epilepsy, 2016, 44, pp.42-47
ISSN
1059-1311
Publisher
Elsevier
Start Page
42
End Page
47
Journal / Book Title
Seizure-European Journal of Epilepsy
Volume
44
Copyright Statement
© 2016, Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Commission of the European Communities
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Identifier
http://www.ncbi.nlm.nih.gov/pubmed/27884611
PII: S1059-1311(16)30201-1
Grant Number
602102
RDA03
RDC04-79560
Subjects
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Neurosciences & Neurology
Epilepsy
Microglia
Positron emission tomography
PET
Translocator protein
TSPO
PROTEIN 18 KDA
TRANSLOCATOR PROTEIN
IN-VIVO
MULTIPLE-SCLEROSIS
ACTIVATED MICROGLIA
RADIOLIGAND BINDING
REFERENCE REGION
BRAIN
NEUROINFLAMMATION
Humans
Image Processing, Computer-Assisted
Positron-Emission Tomography
Receptors, GABA
Neurology & Neurosurgery
1109 Neurosciences
1103 Clinical Sciences
1701 Psychology
Publication Status
Published
Coverage Spatial
England