Stochastic Turing pattern formation in a model with active and passive transport
File(s)patternR.pdf (985.9 KB)
Accepted version
Author(s)
Kim, Hyunjoong
Bressloff, Paul C
Type
Journal Article
Abstract
We investigate Turing pattern formation in a stochastic and spatially discretized version of a reaction–diffusion–advection (RDA) equation, which was previously introduced to model synaptogenesis in C. elegans. The model describes the interactions between a passively diffusing molecular species and an advecting species that switches between anterograde and retrograde motor-driven transport (bidirectional transport). Within the context of synaptogenesis, the diffusing molecules can be identified with the protein kinase CaMKII and the advecting molecules as glutamate receptors. The stochastic dynamics evolves according to an RDA master equation, in which advection and diffusion are both modeled as hopping reactions along a one-dimensional array of chemical compartments. Carrying out a linear noise approximation of the RDA master equation leads to an effective Langevin equation, whose power spectrum provides a means of extending the definition of a Turing instability to stochastic systems, namely in terms of the existence of a peak in the power spectrum at a nonzero spatial frequency. We thus show how noise can significantly extend the range over which spontaneous patterns occur, which is consistent with previous studies of RD systems.
Date Issued
2020-11
Date Acceptance
2020-10-20
Citation
Bulletin of Mathematical Biology, 2020, 82 (11)
ISSN
0092-8240
Publisher
Springer
Journal / Book Title
Bulletin of Mathematical Biology
Volume
82
Issue
11
Copyright Statement
Copyright © 2020 Springer-Verlag. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11538-020-00822-y
Identifier
http://dx.doi.org/10.1007/s11538-020-00822-y
Publication Status
Published
Article Number
144
Date Publish Online
2020-11-07