Combinatorial entropy behaviour leads to range selective binding in ligand receptor interactions
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Published version
Author(s)
Type
Journal Article
Abstract
From viruses to nanoparticles, constructs functionalized with multiple ligands display peculiar
binding properties that only arise from multivalent e ects. Using statistical mechanical modelling,
we describe here how multivalency can be exploited to achieve what we dub range selectivity, that
is, binding only to targets bearing a number of receptors within a speci ed range. We use our model
to characterise the region in parameter space where one can expect range selective targeting to
occur, and provide experimental support for this phenomenon. Overall, range selectivity represents
a potential path to increase the targeting selectivity of multivalent constructs.
binding properties that only arise from multivalent e ects. Using statistical mechanical modelling,
we describe here how multivalency can be exploited to achieve what we dub range selectivity, that
is, binding only to targets bearing a number of receptors within a speci ed range. We use our model
to characterise the region in parameter space where one can expect range selective targeting to
occur, and provide experimental support for this phenomenon. Overall, range selectivity represents
a potential path to increase the targeting selectivity of multivalent constructs.
Date Issued
2020-09-24
Date Acceptance
2020-08-28
Citation
Nature Communications, 2020, 11, pp.1-10
ISSN
2041-1723
Publisher
Nature Research
Start Page
1
End Page
10
Journal / Book Title
Nature Communications
Volume
11
Copyright Statement
© The Author(s) 2020. This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as long as you give
appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party
material in this article are included in the article’s Creative Commons license, unless
indicated otherwise in a credit line to the material. If material is not included in the
article’s Creative Commons license and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly from
the copyright holder. To view a copy of this license, visit http://creativecommons.org/
licenses/by/4.0/.
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as long as you give
appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party
material in this article are included in the article’s Creative Commons license, unless
indicated otherwise in a credit line to the material. If material is not included in the
article’s Creative Commons license and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly from
the copyright holder. To view a copy of this license, visit http://creativecommons.org/
licenses/by/4.0/.
Identifier
https://www.nature.com/articles/s41467-020-18603-5
Publication Status
Published
Date Publish Online
2020-09-24