Morphogen transport in epithelia
File(s)
Accepted version
Author(s)
Bollenbach, T
Kruse, K
Pantazis, P
Gonzalez-Gaitan, M
Juelicher, F
Type
Journal Article
Abstract
We present a general theoretical framework to discuss mechanisms of morphogen transport and gradient formation in a cell layer. Trafficking events on the cellular scale lead to transport on larger scales. We discuss in particular the case of transcytosis where morphogens undergo repeated rounds of internalization into cells and recycling. Based on a description on the cellular scale, we derive effective nonlinear transport equations in one and two dimensions which are valid on larger scales. We derive analytic expressions for the concentration dependence of the effective diffusion coefficient and the effective degradation rate. We discuss the effects of a directional bias on morphogen transport and those of the coupling of the morphogen and receptor kinetics. Furthermore, we discuss general properties of cellular transport processes such as the robustness of gradients and relate our results to recent experiments on the morphogen Decapentaplegic (Dpp) that acts in the wing disk of the fruit fly Drosophila.
Date Issued
2007-01-01
Date Acceptance
2006-08-11
Citation
PHYSICAL REVIEW E, 2007, 75 (1)
ISSN
1539-3755
Publisher
American Physical Society
Journal / Book Title
PHYSICAL REVIEW E
Volume
75
Issue
1
Copyright Statement
© 2007 American Physical Society
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243893400077&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Physical Sciences
Physics, Fluids & Plasmas
Physics, Mathematical
Physics
DPP GRADIENT FORMATION
DROSOPHILA EMBRYO
PATTERN-FORMATION
BICOID PROTEIN
IMAGINAL DISC
DIFFUSION
ENDOCYTOSIS
ROBUSTNESS
MECHANISMS
MOVEMENT
Publication Status
Published
Article Number
ARTN 011901
Date Publish Online
2007-01-02