Pendant-bearing detergents: strategies and membrane protein stabilization
File(s)
Accepted version
Author(s)
Lee, Yewon
Yun, Hong Sik
Ehsan, Muhammad
Byrne, Bernadette
Chae, Pil Seok
Type
Journal Article
Abstract
Membrane proteins (MPs) are vital to many biological processes, making their atomic-level structures essential for drug discovery. Detergent micelles are commonly used in MP research, from extraction, purification, and structure determination. Recently, detergents featuring small pendant groups positioned at the hydrophilic–hydrophobic interface of the micelle have emerged as promising membrane mimetics. This review highlights recent developments in pendant-bearing detergents and explores the roles of pendant groups in MP stabilization. Hydrophobic or hydrophilic pendants enhance alkyl chain packing within micelle interiors through distinct mechanisms. Additionally, reactive pendants enable in situ structural modification of detergents. Pendant-bearing detergents represent valuable tools for MP structural studies and their rational design would pave the way for next-generation detergents to advance MP research.
Date Issued
2025-10-01
Date Acceptance
2025-09-01
Citation
Trends in Chemistry, 2025, 7 (10), pp.617-631
ISSN
2589-5974
Publisher
Elsevier
Start Page
617
End Page
631
Journal / Book Title
Trends in Chemistry
Volume
7
Issue
10
Copyright Statement
Copyright © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. This is the author’s accepted manuscript made available under a CC-BY licence in accordance with Imperial’s Research Publications Open Access policy (www.imperial.ac.uk/oa-policy)
License URL
Subjects
Chemistry
Chemistry, Multidisciplinary
CRYSTALLIZATION
GNG AMPHIPHILES
HEMIFLUORINATED SURFACTANTS
LIPIDS
NANOPARTICLES
PEPTIDES
Physical Sciences
POLYMERS
Science & Technology
SOLUBILIZATION
STABILITY
SYSTEM
Publication Status
Published
Date Publish Online
2025-09-18