SenseBack-an implantable system for bidirectional neural interfacing
File(s)
Author(s)
Type
Journal Article
Abstract
Chronic in-vivo neurophysiology experiments require highly miniaturized, remotely powered multi-channel neural interfaces which are currently lacking in power or flexibility post implantation. In this article, to resolve this problem we present the SenseBack system, a post-implantation reprogrammable wireless 32-channel bidirectional neural interfacing that can enable chronic peripheral electrophysiology experiments in freely behaving small animals. The large number of channels for a peripheral neural interface, coupled with fully implantable hardware and complete software flexibility enable complex in-vivo studies where the system can adapt to evolving study needs as they arise. In complementary ex-vivo and in-vivo preparations, we demonstrate that this system can record neural signals and perform high-voltage, bipolar stimulation on any channel. In addition, we demonstrate transcutaneous power delivery and Bluetooth 5 data communication with a PC. The SenseBack system is capable of stimulation on any channel with ±20 V of compliance and up to 315 μA of current, and highly configurable recording with per-channel adjustable gain and filtering with 8 sets of 10-bit ADCs to sample data at 20 kHz for each channel. To the best of our knowledge this is the first such implantable research platform offering this level of performance and flexibility post-implantation (including complete reprogramming even after encapsulation) for small animal electrophysiology. Here we present initial acute trials, demonstrations and progress towards a system that we expect to enable a wide range of electrophysiology experiments in freely behaving animals.
Date Issued
2020-10-01
Date Acceptance
2020-09-03
Citation
IEEE Transactions on Biomedical Circuits and Systems, 2020, 14 (5), pp.1079-1087
ISSN
1932-4545
Publisher
Institute of Electrical and Electronics Engineers
Start Page
1079
End Page
1087
Journal / Book Title
IEEE Transactions on Biomedical Circuits and Systems
Volume
14
Issue
5
Copyright Statement
© 2020 IEEE. This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/
License URL
Sponsor
Engineering & Physical Science Research Council (E
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000578843800014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
BH141353 (EP/M025977/1)
Subjects
Science & Technology
Technology
Engineering, Biomedical
Engineering, Electrical & Electronic
Engineering
Wireless sensor networks
Wireless communication
Implants
Bluetooth
Field programmable gate arrays
Rodents
Clocks
Bioelectronics
neural interfacing
prosthetics
rodent
WIRELESS
STIMULATION
DEVICE
DESIGN
TOUCH
POWER
Publication Status
Published
Date Publish Online
2020-09-10