Bioglass and bioactive glasses and their impact on healthcare
File(s)
Author(s)
Jones, JR
Brauer, DS
Hupa, L
Greenspan, DC
Type
Journal Article
Abstract
Glass caused a revolution in healthcare when Bioglass was discovered by Larry Hench.
It was the first material to bond with bone, rather than be encapsulated by fibrous
tissue,
launching the field of bioactive ceramics
.
Bioglass is also biodegradable.
Almost 50
years on from
its
discovery that revolution continues.
Bioactive glasses
stimulate more
bone regeneration than other bioactive ceramics
, which is attributed
to their dissolution
products stimulating cells at the genetic level.
This second discovery has changed the
way clinicians, scientists and regulatory bodies
think about medical devices and the
concept of bioactivity. The original 45S5 Bioglass has only re
cently found
really
widespread use in orthop
a
edics, having regenerated the bones of more than 1.5 million
patients.
Its full potential is still yet to be fulfilled.
Th
is
article takes the reader from
Hench’s
Bioglass 45S5
to
its clinical uses and products,
before giving examples of
non
-
surgical
products that now use Bioglass, from consumer products
, such as toothpaste,
to cosmetics
.
Other glasses have also found important healthcare applications, such as
borate based glasses that heal chronic wounds. The re
volution looks set to continue as
new healthcare applications are being found for bioactive glasses, contributing to
extending the glass age.
It was the first material to bond with bone, rather than be encapsulated by fibrous
tissue,
launching the field of bioactive ceramics
.
Bioglass is also biodegradable.
Almost 50
years on from
its
discovery that revolution continues.
Bioactive glasses
stimulate more
bone regeneration than other bioactive ceramics
, which is attributed
to their dissolution
products stimulating cells at the genetic level.
This second discovery has changed the
way clinicians, scientists and regulatory bodies
think about medical devices and the
concept of bioactivity. The original 45S5 Bioglass has only re
cently found
really
widespread use in orthop
a
edics, having regenerated the bones of more than 1.5 million
patients.
Its full potential is still yet to be fulfilled.
Th
is
article takes the reader from
Hench’s
Bioglass 45S5
to
its clinical uses and products,
before giving examples of
non
-
surgical
products that now use Bioglass, from consumer products
, such as toothpaste,
to cosmetics
.
Other glasses have also found important healthcare applications, such as
borate based glasses that heal chronic wounds. The re
volution looks set to continue as
new healthcare applications are being found for bioactive glasses, contributing to
extending the glass age.
Date Issued
2016-11-10
Date Acceptance
2016-09-30
Citation
International Journal of Applied Glass Science, 2016, 7 (4), pp.423-434
ISSN
2041-1294
Publisher
Wiley
Start Page
423
End Page
434
Journal / Book Title
International Journal of Applied Glass Science
Volume
7
Issue
4
Copyright Statement
This is the peer reviewed version of the following article: Jones, J. R., Brauer, D. S., Hupa, L. and Greenspan, D. C. (2016), Bioglass and Bioactive Glasses and Their Impact on Healthcare. Int J Appl Glass Sci, 7: 423–434., which has been published in final form at https://dx.doi.org/10.1111/ijag.12252 This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Subjects
Science & Technology
Technology
Materials Science, Ceramics
Materials Science
bioactive glass
bioglass
wound healing
synthetic bone grafts
bone regeneration
BENIGN BONE-TUMORS
PERIODONTAL INTRABONY DEFECTS
TIBIAL PLATEAU FRACTURES
AUTOGENOUS BONE
FOLLOW-UP
IN-VITRO
DENTIN HYPERSENSITIVITY
CLINICAL-EVALUATION
GRAFT SUBSTITUTES
HUMAN OSTEOBLASTS
Publication Status
Published