14
IRUS TotalDownloads
Altmetric
True Resistant Hypertension Following Observed Drug Ingestion: A Systematic Evaluation
Title: | True Resistant Hypertension Following Observed Drug Ingestion: A Systematic Evaluation |
Authors: | Bunker, J Chang, CL Chapman, N Poulter, N Thom, S Thornton-Jones, L Sever, P |
Item Type: | Journal Article |
Abstract: | The authors investigated the role of poor drug adherence in treatment-resistant hypertension following observed drug ingestion in 102 patients. Median blood pressures (BPs) were 170/91 mm Hg at referral, 153/84 mm Hg prior to, and 142/79 mm Hg during a 4- to 6-hour period after drug ingestion. Median daytime ambulatory BP monitoring (ABPM) over the following 24 hours was 142/80 mm Hg. Median BP at a final follow-up clinic visit was 147/79 mm Hg. The cumulative number of patients achieving a goal of <140/90 mm Hg in clinic or <135/85 mm Hg mean on ABPM was 57 (56%), with a further nine (9%) controlled at the final follow-up clinic visit. Thus, 65% of patients achieved a systolic BP <140 mm Hg at any point immediately prior to, or after, drug ingestion; the residual 35% were considered to have true resistant hypertension. In conclusion, among patients with suspected resistant hypertension, a minority were truly treatment-resistant following observed drug ingestion and BP monitoring. |
Issue Date: | 20-Aug-2016 |
Date of Acceptance: | 23-Jul-2016 |
URI: | http://hdl.handle.net/10044/1/50873 |
DOI: | https://dx.doi.org/10.1111/jch.12896 |
ISSN: | 1751-7176 |
Publisher: | Wiley |
Start Page: | 250 |
End Page: | 255 |
Journal / Book Title: | Journal of Clinical Hypertension |
Volume: | 19 |
Issue: | 3 |
Copyright Statement: | This is the peer reviewed version of the following article: J Clin Hypertens (Greenwich). 2017;19:250–255. 10.1111/jch.12896 © 2016 Wiley Periodicals, Inc., which has been published in final form at https://dx.doi.org/10.1111/jch.12896. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving. |
Sponsor/Funder: | National Institute for Health Research Imperial College Healthcare NHS Trust- BRC Funding National Institute for Health Research |
Funder's Grant Number: | NF-SI-0510-10055 RDC02 79560 NF-SI-0513-10059 |
Keywords: | Science & Technology Life Sciences & Biomedicine Peripheral Vascular Disease Cardiovascular System & Cardiology RENAL DENERVATION CONTROLLED-TRIAL BLOOD-PRESSURE SPIRONOLACTONE STATEMENT 1101 Medical Biochemistry And Metabolomics 1102 Cardiovascular Medicine And Haematology 1103 Clinical Sciences Cardiovascular System & Hematology |
Publication Status: | Published |
Appears in Collections: | National Heart and Lung Institute |